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Metabolic improvements often begin within weeks, before significant weight loss occurs

A wave of regulatory approvals particularly for cardiovascular disease signals broader therapeutic potential, and growing optimism extends to their use in areas such as neurodegenerative disorders and addiction medicine

Persistent high glucose levels increase islet amyloid polypeptides (IAAP) and proinsulin production, resulting in misfolded insulin and IAAP accumulation, and elevated reactive oxygen species (ROS) [14]