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Subjects homozygous for this mutation ( MTHFR 677TT genotype) exhibit reduced MTHFR activity and increased risk for a wide variety of cancers (41-43), but the evidence of an association between this polymorphism and cancer is inconsistent, with some reports suggesting a reduction in colorectal cancer risk with the T allele (44)
The apolipoprotein E 4 (APOE4) allele confers the highest risk for AD, whereas APOE2 acts protectively
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