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The crystalline lens is highly sensitive to osmotic changes, and shifts in blood glucose alter the fluid balance within the lens, changing its shape and refractive properties
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For oral semaglutide, the PIONEER 6 trial showed non-inferiority for cardiovascular safety, though it is important to note that Rybelsus does not have a specific licensed indication for cardiovascular risk reduction in the UK
Future research will investigate the impact of semaglutide on a broader range of neuroendocrine tumor models, including three-dimensional patient-derived tumor cultures
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