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Because it is not an approved drug, the retatrutide sold online is supplied as a research compound
The medication slows gastric emptying as part of how it works, which creates conditions that can push stomach acid upward into the esophagus
These include metformin, which can be used alongside GLP-1 medications (see our guide on taking metformin and tirzepatide together ), as well as naltrexone and bupropion
At the same time, semaglutide slows gastric motility, which means you digest food more slowly and feel fuller for longer
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