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In the STEP and SURMOUNT trials: Constipation was reported in up to 24% of patients on semaglutide 18-23% of patients on tirzepatide experienced constipation It is one of the top three side effects of these medications and is more frequent in those who: Lose weight rapidly Eat low-fiber diets Are female (due to hormonal factors affecting gut motility) Conventional Treatment Approaches Most providers recommend over-the-counter (OTC) remedies such as: Stool softeners (docusate) Fiber supplements (psyllium, methylcellulose) Laxatives (PEG 3350, senna, Mag Citrate) These can help in the short term but do not address the root cause
0.25 mg of semaglutide equals 25 units on a U-100 insulin syringe when your vial is 1 mg/mL the most common compounded strength
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Overall adverse events in PIONEER 9 and 10 were consistent with the other PIONEER studies with 67% to 85% of patients reporting AEs over 52 weeks
