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The efficacy and safety profile of naltrexone-bupropion has been established by several multicentre randomised double-blind placebo-controlled trials in the Contrave Obesity Research (COR) programme, including the Contrave Obesity Research-I (COR-I) study, the Contrave Obesity Research-II (COR-II) study, and the Contrave Obesity Research-Intensive Behavior Modification study (COR-BMOD) [9,10,11]
Department of Health and Diabetes UK (2005) Structured patient education in diabetes: report from the Patient Education Working Group
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Prescription records served as proxies for medication exposure, without confirmation of actual adherence
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