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However, certain triggers may stimulate melanocytes to produce excess pigment

W.WagemakersL.SchoutenA.van KanJ

NRF2 and cancer NRF2 is frequently mutated in many types of cancers, with the mutations clustered around the DLG (43 %) and ETGE (57 %) motifs, which are the two critical KEAP1 interaction domains [95]