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Alcohol Several studies investigating exendin-4, liraglutide, dulaglutide and semaglutide in rats and mice found a decrease in alcohol use, which was mediated by mesolimbic dopamine pathways involving the nucleus accumbens, the ventral tegmental area and the ventral hippocampus, the dorso-lateral septum, and the nucleus of the solitary tract 59,60,61,63,64,65,66,67,68,69,72,74,75,76,77,79,80,81,82,106
Hypoxic conditions can also lead to a phenomenon known as DPP-4 shedding whereby transmembrane DPP-4 is cleaved from the membrane and released into the circulation in a soluble form
Some research suggests that side effects tend to decrease after about six months
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