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The case reports involved patients aged 56 and 75, but whether age is a risk factor or simply reflects the demographics of semaglutide users is unclear
Mechanistically, they found that liraglutide inhibited the renal TNF- expression and NF-B as well as the MAPK pathway activation in these mice (Ye et al., 2019)
speculation includes endogenous IGF-1 axis suppression or downstream insulin/glucose dynamics
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