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As for the formulation, Pete said, A two-capsule serving contains 270 milligrams of caffeine, which is a strong dose and could elicit side effects. He did note that there are clear instructions on the label warning people not to take the supplement on an empty stomach, and to avoid taking it within six hours of going to sleep

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For example, it is probably advisable to hold GLP-1 agonists for patients with a recent initiation or dose increase who are more likely to be in the throes of gastrointestinal side effects

Nat Med (2011) 17(11):14907.10.1038/nm.2461 126 LimJIyerALiuLSuenJYLohmanRJSeowVet alDiet-induced obesity, adipose inflammation, and metabolic dysfunction correlating with PAR2 expression are attenuated by PAR2 antagonism