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The AF1 contains two separable transcription activation units [Tau-1 (amino acids 100370] and Tau-5 (amino acids 360485)) that are indispensable for full activity of the AR (Figure 1B) 39

Roughly 5-10% of patients report temporary metallic taste or dulled flavor, usually resolving within 4-6 weeks

It is marketed under the brand names Wegovy, specifically for weight management, and Ozempic, approved for type 2 diabetes