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-site amyloid precursor protein-cleaving enzyme 1 (BACE1) and -secretase are key rate-limiting enzymes in the cleavage of amyloid APP to produce A (218, 219)
Delivered via AAV9, a single intracisternal dose enabled sustained brain expression for months and reduced pathological TDP-43 levels in translational mice (Val et al., 2025)
IV glutathione carries small risks of allergic reaction and cost burden
With tesamorelin, the two-month results are typically visible in the abdominal region
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