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The FDA has determined that NAC is excluded from the statutory definition of a dietary supplement under the Federal Food, Drug, and Cosmetic Act, because NAC was authorized as an active pharmaceutical ingredient (for acetaminophen overdose) before it was widely marketed as a supplement
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Medication interactions : Melatonin can affect how other drugs work
However, baseline liver function tests may be appropriate for patients with known liver disease or elevated transaminases, with individualized monitoring based on clinical judgment
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