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The effects of insulin on glucose and lipid metabolism are mainly mediated by the IRTK-induced phosphorylation of IRS, which then recruits phosphatidylinositol-3-OH kinase (PI3K) and catalyzes the production of phosphatidylinositol-3,4,5-trisphosphate (PIP3) from phosphatidylinositol-4,5-bisphosphate (PIP2)
The most common side effects reported in Phase 2 trials include nausea, diarrhea, vomiting, and constipation
And it was during the trial of individuals with diabetes that it was noted that they were also losing weight and had a reduction in their appetite
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