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The SURPASS and SURMOUNT trials suggest tirzepatide produces greater average weight loss than semaglutide, likely due to its dual GIP and GLP-1 receptor activation
This regulatory structure differs from the rigorous approval process brand-name drugs undergo, which includes extensive clinical trials and manufacturing oversight
Even though the brain appears to have plenty of GLP-1 receptors, GLP-1 seemingly cannot pass from the blood to access those receptors, says Stefan Trapp, PhD, a professor of autonomic neuroscience and metabolic disease at University College London
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