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Reduced fat storage
If you do not take your HRT orally (for example, you use a patch, a gel or a Mirena coil instead of a tablet) then you do not need to worry
However, the largest Phase IIb trial involving 536 participants failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading to development termination in 2007
Keep unreconstituted lyophilized vials cold and away from light, and never freeze the reconstituted solution
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