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Neoplastic transformation of the peribiliary stem cell niche in cholangiocarcinoma arisen in primary sclerosing cholangitis

Among the top 50 hits (proteins most enriched by LaccID in TCR-T cell coculture versus monoculture) were 33 proteins with direct literature links to CD8 + T cell activation, another 3 proteins with indirect links, 2 membrane proteases (ADAM19 and FURIN) and 8 mitochondrial proteins (Fig

An elevated methylmalonic acid (MMA) level has been thought to be the most direct, metabolic indicator of B12 deficiency because B12 is the only cofactor required by the enzyme that degrades MMA

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