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Consequently, on top of the beneficial effect of weight loss caused by GLP-1 analogues these drugs also cause a substantial reduction of the glycemic load (GL = carbohydrate intake X Glycemic index), which per se reduces hyperinsulinemia and causes weight loss [22], reduce diabetes risk [23], inflammation [24], and cardiovascular risk [25]

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While improved metabolic health and weight loss might theoretically reduce fatigue burden, semaglutide's gastrointestinal effects and associated dehydration could potentially worsen fatigue in some individuals

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