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Gastrointestinal surgery can also affect B12 absorption

MADD is a disorder that results from mutations in either of the two genes that encode the protein components of the heterodimeric complex identified as electron transfer flavoprotein (ETF) or the gene encoding electron transfer flavoprotein dehydrogenase (encoded by the ETFDH gene)

A pharmacokinetic study in rats found that oral administration produced substantial plasma concentrations, with a maximum concentration of 2252 ng/mL and an elimination half-life of approximately 6.9 hours

Yes, combining B12 therapy with physical therapy and pain management can enhance treatment