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As predicted by preclinical studies with EPO (5) and ARA 290 (10,38), subjects receiving ARA 290 exhibited significant improvement in glucose control as shown by changes in Hb A 1c concentration
To date, GLP-1 RAs have demonstrated efficacy in obese patients with HFpEF, but data in HFrEF remain scarce
In the setting of chronic immune activation, a rise in circulating succinyladenosine is therefore consistent with heightened purine synthesis/turnover in proliferating immune and stromal cells ( Conversely, depletion of certain nucleosides, such as inosine and cytidine, may reflect their rapid utilization during immune-cell proliferation or altered enzymatic processing, such as increased cytidine deaminase activity
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