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2.1.3 Peficitinib Peficitinib is an oral pan-JAK inhibitor that was studied in a Phase 2b dose-ranging RCT (NCT01959282) evaluating four dosing regimens (25 mg once daily, 75 mg once daily, 150 mg once daily, and 75 mg twice daily) versus placebo in 219 patients with moderate-to-severe UC ( 2.1.4 Oncostellae Oncostellae (OST-122) is an oral, gut-restricted JAK3/TYK2/5 adenosine monophosphateactivated protein kinaserelated kinase 5 (ARK5) inhibitor designed for localized treatment of IBD with minimal systemic absorption to reduce toxicity risks associated with other JAK inhibitors

For patients currently seeking weight management support in the UK, NICE-approved pathways remain the appropriate route

Obesity As described above, overweight and obesity are far too prevalent, with roughly 75% of U.S