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Real-world averages run lower because of discontinuation and under-titration: 13 to 18% on tirzepatide and 8 to 14% on semaglutide over 12 months
Overweight: BMI of 27 or higher with at least one weight-related health condition, like type 2 diabetes, high blood pressure, or high cholesterol
CANTT BE USED: Below knees, or if Pregnant
A study presented at ENDO 2025 by the Endocrine Society confirmed what many clinicians had suspected: higher protein intake appears to protect against muscle loss in patients taking semaglutide
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