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Additionally, oxidative stress promotes further ROS production and influences the activity of cysteine-dependent proteases [30]
Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P et al (2018) Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
Therefore, highly dynamic ratio of cystine/cysteine couple in vivo can explain the discrepancy with in vitro phenotype
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