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According to the FDA prescribing information for Zepbound, the most common gastrointestinal adverse reactions in the SURMOUNT clinical trials included nausea (24-30%), diarrhea (18-24%), vomiting (8-12%), constipation (16-17%), dyspepsia (5-9%), and abdominal pain (6-10%), with rates varying by dose

The accumulation of Galactose in PC cells leads to changes in mitochondrial morphology and affects the expression of mitochondrial division protein Fis-1, thereby promoting apoptosis (Deng et al., 2022)

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