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Liver injury caused by acetaminophen is initiated by cytochrome P450 (CYP)-mediated bioactivation to N -acety- para -benzoquinoneimine (NAPQI), which is a chemically reactive intermediate that is formed at high levels following overdosage and triggers a complex cascade of events, which ultimately result in hepatocellular necrosis (Hinson et al
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In many fish species, high dietary carbohydrate induced lower growth, excess lipid deposition, and decreased stress resistance 38,39,40
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