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Researchers who are sensitive to gastrointestinal side effects or who have experienced significant issues with semaglutide constipation or tirzepatide GI issues may find cagrilintide monotherapy more tolerable, even at the cost of somewhat lower weight loss
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As you titrate to a maintenance dose your monthly drug cost may increase, unless the program locks a flat price
In phase 3 trials, maximal dose retatrutide demonstrated 29% placebo-adjusted weight loss at 68 weeks (albeit with higher discontinuation rates than semaglutide and tirzepatide)
![GLP 2 [Tyr34] (1-34), human](https://www.echelon-inc.com/wp-content/uploads/2019/11/471-19.jpg)
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