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These two substitutions , the Nle4 and D-Phe7 modifications and were introduced through the systematic structure-activity relationship programme in Victor Hrubys laboratory at the University of Arizona that established the pharmacophore requirements for melanocortin receptor agonism and produced MT-1 as a more potent, metabolically stable, and pharmacologically tractable research tool than native -MSH

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g ) Comparison of AUC values calculated from iSim drug-drug similarity estimated from drug profiles in the same cell line 24 and 48 hours after drug exposure