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High fever affects multiple body systems: Increases fluid loss through sweating Accelerates metabolism and energy expenditure Can affect how medications are processed May indicate bacterial infection requiring antibiotics Gastrointestinal Illness Stomach bugs, food poisoning, or severe gastrointestinal flu present special challenges on GLP-1 therapy

A post hoc subgroup analysis assessing changes in BMI standard-deviation scores between participants with one or more gastrointestinal adverse events and those with none revealed that the effect of liraglutide in reducing BMI standard-deviation scores was independent of gastrointestinal adverse events (P = 0.82) (245)

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In NAFLD mice, liraglutide could improve the hypoadiponectinemia-induced inflammatory stress by inhibiting the MKK4/JNK signaling pathway, inhibit liver adipogenesis by activating AMPK, and induce autophagy through the AMPK/mTOR pathway, hence improving the levels of liver lipids (198)