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They may return to a worse body-composition phenotype: more fat mass regained less muscle recovered poorer insulin sensitivity greater metabolic fragility That could help explain why risk appears to rebound so quickly after discontinuation
Both conditions may require corticosteroids for acute flares, immunomodulators (azathioprine, 6-mercaptopurine), and biologic therapies (anti-TNF agents, vedolizumab, ustekinumab) for moderate to severe disease
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Insulin action on glucose and protein metabolism during L-carnitine supplementation in maintenance haemodialysis patients
