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This can be histopathologically elicited as melanocytic hyperplasia
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Additionally, a combination of CCNA1 (cyclin A1) and VIM biomarkers has demonstrated a sensitivity of 90.3% and a specificity of 91.7% in detecting BE metaplasia following DNA methylation (Moinova et al., 2018)
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Endogenous GH release occurs primarily during slow-wave sleep, and GHS-R1a activation can influence sleep architecture
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