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Specific proteins reported to be upregulated in CVD (but downregulated with semaglutide treatment, after adjusting for effects of weight loss and HbA 1c reduction) include NPPB (NT-proBNP, released from cardiomyocytes on ventricular distension) 37 , ANGPT2 (involved in vascular remodeling and angiogenesis) 38 , CD93 (involved in cardiovascular homeostasis) 39 , MSR1 (involved in lipid metabolism and immune function) 40,41 , and THBS2 and TNC (both involved in extracellular matrix remodeling) 42
Curculigoside isolated from ethanolic extract of Curculigo orchioides possesses multiple significant activities, in which it is also known to show significant response in enhancing bone loss at 100 mg/kg treated orally in mutagenic transgenic mice [93].Other researchers also reported that Curculigo orchioides is one of the natural Chinese medicine and it has been known to have anti-osteoporosis activity [94].Additionally, researchers also claimed that curculigoside is known to be one of the main bioactive phenolic compound of Curculigo orchioides
A comprehensive evaluation that considers both hormonal status and weight management goals gives providers the most complete picture for developing an effective treatment plan
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