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GHS-R1a activation triggers Gq/11 protein coupling, which stimulates phospholipase C, generates IP3 and diacylglycerol, and mobilizes intracellular calcium to drive GH exocytosis from secretory granules
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In hepatocytes from mice in which the TKT gene was knocked out there is an accumulation of ribose-5-phosphate as well as the nucleotides, inosine, adenosine, and deoxyadenosine
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