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Earlier amylin analogs like pramlintide were short-acting and needed dosing with every meal, which made them a hassle and limited their reach
Biochem Eng J
Distinct interactions between c-Src and c-met in mediating resistance to c-Src inhibition in head and neck cancer
[1] [2] The reduced IGFBP interaction results in less plasma sequestration, allowing more active peptide to remain concentrated near the injection site and contributing to its localized anabolic profile
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