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Caputo R, Buono G, Piezzo M, Martinelli C, Cianniello D, Rizzo A, et al
Current protocols recommend treating patients with an initial dose of 150 mg/kg NAC, infused over a period of an hour, upon hospitalization, followed by decreasing amounts of NAC infused over the next 20 hours
The compound was developed from work on Epithalamin, a mixture of low-molecular-weight peptides extracted from bovine pineal tissue
Another challenge for nose-to-brain drug delivery is the development of appropriate delivery devices, since standard devices are optimized for local effects and therefore deliver only a small amount of drug to the olfactory region [65]
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