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The cleavage of GIP(1-30)NH 2 subsequently results in GIP(3-30)NH 2 , a fragment that binds to the human GIP receptor with high affinity but does not have any intrinsic activation of the human GIP receptor in physiological concentrations ( Figure 1 The human GIP receptor can be found in multiple organs and tissues, reflecting its various physiological functions ( Beyond the pancreatic islet cells, the GIP receptor is expressed within the vascular system, including the heart and various endothelial cells
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Current evidence suggests a risk-stratified approach, with most patients able to continue therapy with appropriate precautions, while some higher-risk individuals may benefit from temporary medication adjustments
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