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Several studies have optimized urea-containing compounds such as SBI-797812 and 1-(2-phenyl-1,3-benzoxazol-6-yl)-3-(pyridin-4-methyl)urea (DS68702229) as potent NAMPT activators, which have been shown to increase NAD + levels in vitro and in vivo, with potential applications in treating metabolic disorders, cardiovascular diseases, and neurodegeneration preclinically 221,222

Peptides like Selank and Semax, primarily known for their anxiolytic and cognitive effects, may have indirect benefits for psoriasis through stress reduction

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Synergistic Effects Synergistic effects refer to when two or more agents act together to generate an activity greater than the sum of their individual activities