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A subsequent scRNA-seq study on human islets documented a similar alpha-cell subpopulation consisting of a small number of proliferating alpha-cells, expressing TOPA1 , CENPF , and AURKB (72)
These disparities may be related to differences in cell type (salivary gland versus lymphocyte) or readouts (glutathione/senescence versus viability)
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High-protein intake is particularly important during GLP-1-mediated weight loss because it preserves lean muscle mass, enhances satiety (complementing the drug's effects), and stimulates endogenous PYY release for additional appetite control
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