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In diseases where amino-acid metabolizing enzymes are dysfunctional or absent (e.g., propionic acidemia and methylmalonic acidemias characterized by neurological symptoms, muscle weakness and low energy) C3 accumulates, and higher blood levels are used as a screening tool

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L-methylmalonyl-CoA to Succinyl-CoA Conversion: Methylcobalamin is also a coenzyme for the enzyme methylmalonyl-CoA mutase

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