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GH pulsatility may matter for receptor sensitivity and downstream IGF-1 signaling at the tissue level, but the optimal pulse pattern in adults is not established
Funding Open access funding provided by University of Eastern Finland (UEF) including Kuopio University Hospital
These are less likely to happen when the dose is started low and increased slowly, and they usually get better over time
The primary limitation is the gap between preclinical and human data
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