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The unfolded protein response within ER activate the PERK-NRF2 axis, inducing antioxidant gene expression to alleviate oxidative stress [143]
It is well tolerated, easy for patients to self-administer, and it keeps mitochondrial support steady through the period when the body is doing the most cellular work
[13] Also in 2004, Harran and co-workers reported a dimeric small molecule that mimics the proapoptotic protein Smac (see mitochondrial regulation in apoptosis)
A: In many regions, these peptides are not approved as prescription drugs for general therapeutic use, and human evidence varies by compound and indication
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