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Presented for research literature review only Nave R et al
These peptides activate MRGPRX2, a mast-cell receptor that fires on positively charged, aromatic molecules and releases histamine into the tissue. Sodium and chloride ions screen the peptides positive charge, so the receptor sees less of it and the welt shrinks
That's sub-picomolar sensitivity essential for detecting GSH-PX in samples where expression may be low, such as in certain cell lines or diluted biological fluids
J Exp Med 217:20201129
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