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doi:10.1155/2012/324832 4
The PPP in erythrocytes is the only pathway for these cells to produce NADPH, therefore, any defect in the production of NADPH, such as due to deficiencies in glucose-6-phosphate dehydrogenase, will have profound effects on erythrocyte survival
Several enzymes involved in ATP production contain Fe-S clusters in the active site and are subject to similar inactivation by superoxide, including oxoglutarate dehydrogenase of the tricarboxylic acid cycle, as well as ETC complexes IIII
Their mechanism involves enhancing mitophagy, suppressing NLRP3 inflammasome activation in hepatocytes, and modulating key metabolic regulators
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