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Togo et al .[35] found that fibroblasts isolated from COPD patients exhibited reduced chemotaxis, reduced nuclear to cytoplasmic ratios of phosphorylated SMAD3, and decreased -smooth muscle actin production compared to controls when treated with TGF
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When tissue is damaged by injury, inflammation or oxidative stress extracellular matrix proteins (notably collagen and SPARC) are broken down, releasing peptide fragments including GHK
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The Zagreb research group's work is notable for its methodological consistency and the breadth of applications studied
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