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Studies on athletes show whole-body cryotherapy reduces circulating levels of the pro-inflammatory cytokine IL-1 beta while increasing the anti-inflammatory cytokine IL-10 and the cytokine inhibitor IL-1 receptor antagonist (IL-1ra)

The most appropriate route depends on the specific research application

It is primarily produced in the central nervous system, and was first isolated from the brains of rabbits that were subjected to sleep by electric stimulation of the intralaminal thalamic area

Table of Contents Toggle Literature Scope and Evidence Hierarchy This article is an evidence-informed narrative review rather than a systematic review or meta-analysis