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Participants receiving higher studied doses generally achieved larger average changes, although individual responses varied
Interaction with existing medical conditions or therapies
Standard clinical escalation protocol The Phase 2 trial published in the New England Journal of Medicine established the titration schedule that most researchers follow
Animals Male Sprague-Dawley rats (7 weeks old, 200250 g), male C57BL/6 mice (8 weeks old, 2025 g), and male C57BLKsJ- db/db mice (7 weeks old, 3035 g) were acquired from OrientBio Inc
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