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Firstly, through a systematic review and network meta-analysis, researchers have assessed the effects of GLP-1R agonists on neuroinflammation and reported that, compared with placebo, GLP-1R agonists significantly reduce the levels of neuroinflammatory markers, such as TNF- and interleukin-1 (Urkon et al., 2025

The convergence of enabling technologies, conceptual shifts toward polypharmacology, improved mechanistic tools, and evolving regulatory frameworks has fundamentally altered the translational calculus