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Malaguarnera, M., Vacante, M., Motta, M., Giordano, M., Malaguarnera, G., Bella, R., Nunnari, G., Rampello, L., and Pennisi, G

Although this class of drugs has been FDA-approved and used to treat type 2 diabetes since 2005, their use as a treatment for obesity and the explosion in public awareness that followed has been a more recent development

validated the beneficial effects of liraglutide on food intake, body weight, insulin resistance, and hepatic steatosis in HFD-fed mice and proposed that liraglutide treatment activated the autophagy-lysosomal-dependent lipid degradation [19]

In vitro research and preliminary clinical research show that berberine moderately inhibits CYP3A4