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Discussion Mitochondrial malfunction is a prominent feature of diabetes, encompassing defects in mitochondrial structure and dynamics, ROS overproduction and apoptosis, breakdown of nutrient sensing, and metabolic uncoupling 55, 56 , with strong backing evidence from human genetic studies 57, 58, 59
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Current users of compounded or custom-mixed drugs were more likely to have switched from brand-name medications than vice versa (35% vs 10%), with cost or insurance coverage cited as the primary reason by 66% of those who switched to compounded versions
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