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The 40 percent non-response rate tells us something important: psoriasis is not driven by a single pathway but by a network, and interrupting one node does not always collapse the entire system
It also plays a role in immune function and mood regulation
Li N, Alam J, Venkatesan MI, Eiguren-Fernandez A, Schmitz D, et al: Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals
The Journal of clinical investigation 124, 42044211 (2014)
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