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Description

Tumors with inherited or somatic deficiencies in HRR genes, such as BRCA1, BRCA2, PALB2, and RAD51, exhibit synthetic lethality to PARPis, including olaparib, rucaparib, niraparib, and talazoparib, which have shown durable efficacy in BRCA-mutant breast, ovarian, and prostate cancers

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Schizophrenia: glutathione deficit in cerebrospinal fluid and prefrontal cortex in vivo

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